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学术报告:A Journey in Process Chemistry: Development of a Practical Synthesis of ERK Inhibitor and TAC Linker Drug
2017-06-19

报告题目:A Journey in Process Chemistry: Development of a Practical Synthesis of ERK Inhibitor and TAC Linker Drug

报告人:美国Genentech制药公司令狐欣博士

报告时间:2017年7月3日下午4点

报告地点:石先楼报告厅

报告人简历:令狐欣博士1997年本科毕业于南开大学,2000年硕士毕业于北京化学所,2005年博士毕业于美国北卡大学(导师:Jeffrey Johnson教授),博士毕业后师从美国加州大学伯克利分校Dean Toste教授从事博士后研究。2007年进入美国Merck制药公司从事药物工艺研究,2012年进入美国Genentech制药公司从事小分子药物的制药工艺研发工作。

报告摘要:Pharmaceutical process chemistry is a multidimensional discipline that transforms a sequence of reactions into a viable manufacturing process for a drug candidate. The high chemical complexity of modern pharmaceuticals presents a challenge to process chemists. In this presentation, process chemistry efforts on development of a practical synthesis of an ERK Inhibitor and TAC linker drug will be discussed. These two process chemistry case studies demonstrate both incremental and innovative changes to improve the synthetic efficiency of the original discovery chemistry sequence, delivering a large quantity of active pharmaceutical ingredients (APIs) in high purity in support of preclinical and clinical studies.