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Xi Zhen

Cheung Kong Scholar Distinguished Professor

Subject: Chemical Biology, Plant Protection

Address:Rm 102, Institute of Elemental-Organic Chemistry, Nankai University, 94# Weijin Road, Tianjin 300071, China

Telephone: 23504782

E-Mail: zhenxi@nankai.edu.cn

Website:

Research Interest:
1. Chemical Biology of Nucleic Acids´╝Ť
2. Molecular Basis of Pesticide Resistance´╝Ť
3. QSAR on Biomolecular Selectivity and Drug Resistance.







History:
B.S, 1983, Central China Normal University;
M.S, 1988, Nankai University;
Ph.D, 1994, Uppsala University;
Research Fellow, 1994-2001, Harvard Medical School
Professor, 2001-present, Nankai University, China.







Honors and Awards:
Eli Liley Research Excellence Award (China), 2006.
National Outstanding Oversea Returnee, 2009.
Tianjin Labor Medal, 2010.







Selected publications:
1.5-Formylcytosine Yields DNA-Protein Cross-Links in Nucleosome Core Particles, F.-C. Li, Y.-Q. Zhang, J. Bai, M.-M. Greenberg, Z. Xi, C.-Z. Zhou, J. Am. Chem. Soc. 2017, 139, 10617-10620.
2.Thiol Specific and Tracelessly Removable Bioconjugation via Michael Addition to 5-Methylene Pyrrolones, Y.-Q. Zhang, X.-P. Zhou, Y.-H. Xie, M.-M. Greenberg, Z. Xi, C.-Z. Zhou, J. Am. Chem. Soc. 2017, 139, 6146-6151.
3.A New H2S-specific Near-infrared Fluorescence-enhanced Probe That Can Visualize the H2S Level in Colorectal Cancer Cells in Mice, K. Zhang, J. Zhang, Z. Xi, L.-Y. Li, X.-X. Gu, Q.-Z. Zhang, L. Yi, Chem. Sci. 2017, 8, 2776-2781.
4.A Redox-Nucleophilic Dual-Reactable Probe for Highly Selective and Sensitive Detection of H2S: Synthesis, Spectra and Bioimaging, C.-Y. Zhang, R.-Y. Wang, L.-H. Cheng, B.-J. Li, Z. Xi, L. Yi, Sci. Rep. 2016, 6, 30148.
5.Dual-Reactable Fluorescent Probes for Highly Selective and Sensitive Detection of Biological H2S, C. Wei, R.-Y. Wang, C.-Y. Zhang, G.-C. Xu, Y.-Y. Li, Q.-Z. Zhang, L.-Y. Li, L. Yi, Z. Xi, Chem. Asian J. 2016, 11, 1376-1381.
6.Fast-Response Turn-on Fluorescent Probes Based on Thiolysis of NBD Amine for H2S Bioimaging, R.-Y. Wang, Z.-F. Li, C.-Y. Zhang, Y.-Y. Li, G.-C. Xu, Q.-Z. Zhang, L.-Y. Li, L. Yi, Z. Xi, ChemBioChem. 2016, 17, 962-968.
7.Branch-PCR Constructed Stable shRNA Transcription Nanoparticles Resulted in Long-lasting RNAi Effect, J.-B. Liu, R.-Y. Wang, D.-J. Ma, Y.-Y. Li, C. Wei, Z. Xi, ChemBioChem. 2016, 17, 1038-1042.
Flexible DNA Junction Assisted Efficient Construction of Stable Gene 8.Nanoparticles for Gene Delivery, J.-B. Liu, Y.-Y. Li, D.-J. Ma, D. Ouyang, Z. Xi, Chem. Comm. 2016, 52, 1953-1956.
9.A Dual-Response Fluorescent Probe Reveals the H2O2 -Induced H2S Biogenesis Through a Cystathionine Beta-Synthase Pathway, L. Yi, L. Wei, R.-Y. Wang, C.-Y. Zhang, J. Zhang, T.-W. Tan, Z. Xi, Chem. Eur. J. 2015, 21, 15167-15172.
10.A highly Selective and Fast-response Fluorescent Probe for Visualization of Enzymatic H2S Production in Vitro and in Living Cells, L. Wei, Z.-T. Zhu, Y.-Y. Li, L. Yi, Z. Xi, Chem. Comm. 2015, 51, 10463-10466.
11.Efficient Construction of Stable Gene Nanoparticles Through Polymerase Chain Reaction with Flexible Branched Primers for Gene Delivery, J.-B. Liu, R.-Y. Wang, D.-J. Ma, D. Ouyang, Z. Xi, Chem. Comm. 2015, 51, 9208-9211.
12.A FRET-ICT Dual-quenching Fluorescent Probe with Large Off-on Response for H2S: Synthesis, Spectra and Bioimaging, C.-Y. Zhang, L. Wei, C. Wei, J. Zhang, R.-Y. Wang, Z. Xi, L. Yi, Chem. Comm. 2015, 51, 7505-7508.
13.Self-assembled Controllable Virus-like Nanorods as Templates for Construction of One-dimensional Organic-inorganic Nanocomposites, D.-J. Ma, Y.-H. Xie, J. Zhang, D. Ouyang, L. Yi, Z. Xi, Chem. Comm. 2014, 50, 15581-15584.
14.FRET Ratiometric Probes Reveal the Chiral-sensitive Cysteine-Dependent H2S Production and Regulation in Living Cells, L. Wei, L. Yi, F.-B. Song, C. Wei, B.-F. Wang, Z. Xi, Sci. Rep. 2014, 4, 4521.
15.Understanding Resistance Mechanism of Protoporphyrinogen Oxidase-Inhibiting Herbicides: Insights from Computational Mutation Scanning and Site-Directed Mutagenesis, G.-F. Hao, Y. Tan, W.-F. Xu, R.-J. Cao, Z. Xi, G.-F. Yang, J. Agri. Food Chem. 2014, 62, 7209-7215.
16.o-Fluorination of Aromatic Azides Yields Improved Azido-Based Fluorescent Probes for Hydrogen Sulfide: Synthesis, Spectra, and Bioimaging, C. Wei, R.-Y. Wang, L. Wei, L.-H. Cheng, Z.-F. Li, Z. Xi, L. Yi, Chem. Asian J. 2014, 9, 3586-3592.
17.NBD-based Colorimetric and Fluorescent Turn-on Probes for Hydrogen Sulfide, C. Wei, Q. Zhu, W.-W. Liu, W.-B. Chen, Z. Xi, L. Yi, Org. Biomol. Chem. 2014, 12, 479-485.
18.Single Modification at Position 14 of siRNA Strand Abolishes Its Gene-silencing Activity by Decreasing Both RISC Loading and Target Degradation, J. Zheng, L. Zhang, J.-B. Zhang, X.-X. Wang, K.-Q. Ye, Z. Xi, Q. Du, Z.-C. Liang, FASEB J. 2013, 27, 4017-4026.
19.Quantitative Structural Insight into Human Variegate Porphyria Disease, B. -F. Wang, X. Wen, X.-H. Qin, Z.-F. Wang, Y. Tan, Y.-Q. Shen, Z. Xi, J. Biol. Chem. 2013, 288, 11731-11740.
20.Highly Potent and Stable Capped siRNAs with Picomolar Activity for RNA Interference, L. Wei, L,-Q. Cao, Z. Xi, Angew. Chem. Int. Ed. 2013, 52, 6501-6503.