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Xiong Hu

Hundred Young Talents of Nankai University

Subject: Analytical Chemistry

Address:616 North Chemistry Building, Nankai University, 94 Weijin Road, Tianjin

Telephone:

E-Mail: xionghu@nankai.edu.cn

Website:

Research Interest:
NIR-I/II imaging, Bioluminescence imaging, photoacoustic imaging, Photothermal therapy, Photodynamic therapy

History:
2005-2009 B.S. in Chemistry, Zhengzhou University
2009-2014 Ph.D. in Organic Chemistry, Shanghai Institute of Organic chemistry, CAS. (Supervisor: Yong Tang & Zuowei Xie)
2014-2018 Postdoc, UTSouthwestern Medical Center (with Prof. Daniel J. Siegwart)
2008- Professor, Research Center for Analytical Science, Nankai University

Honors and Awards:

Selected publications:
Selected publications´╝Ü
(1) Xiong, H., Zhou, K., Yan, Y., Miller, J. B., Siegwart, D. J. Tumor activated water-soluble photosensitizers for near-infrared photodynamic cancer therapy. ACS Applied Materials & Interfaces, 2018, 10, 16335-16343.
(2) Xiong, H., Zuo, H., Yan, Y., Occhialini, G., Zhou, K., Wan, Y., Siegwart, D. J. High-contrast fluorescence detection of metastatic breast cancer including bone and liver micrometastases via size-controlled pH-activatable water-soluble probes. Advanced Materials, 2017, 29, 1700131.
(3) Xiong, H., Kos, P., Yan, Y., Zhou, K., Miller, J. B., Elkassih, S., Siegwart, D. J. Activatable water-soluble probes enhance tumor imaging by responding to dysregulated pH and exhibiting high tumor-to-liver fluorescence emission contrast. Bioconjugate Chemistry, 2016, 27, 1737-1744.
(4) Xiong, H., Xu, H., Liao, S., Xie, Z., Tang, Y. Copper-Catalyzed Highly Enantioselective Cyclopentannulation of Indoles with Donor-Acceptor Cyclopropanes. J. Am. Chem. Soc. 2013, 135, 7851-7854. (Highlighted in SYNFORM 2013, 10, 122.)
(5) Miller, J. B., Zhang, S., Kos, P., Xiong, H., Zhou, K., Perelman, S. S., Zhu, H., Siegwart, D. J. Non-viral CRISPR/Cas gene editing in vitro and in vivo enabled by synthetic nanoparticle co-delivery of Cas9 mRNA and sgRNA. Angew. Chem. Int. Ed. 2017, 56, 1059-1063.
(6) Zhou, K., Nguyen, L. H., Miller, J. B., Yan, Y., Kos, P., Xiong, H., Li, L., Hao, J., Minnig, J. T., Zhu, H., Siegwart, D. J. Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model. Proc. Natl. Acad. Sci. U. S. A. 2016, 113, 520-525.