Catalytic Organic Synthesis
Prof. Shou-Fei Zhu's research interests focus on catalytic organic synthesis, particularly those involving hydrogen transfer as key steps. He developed novel "chiral proton shuttle" catalysts for metal-catalyzed reactions, which can realize efficient chiral control of proton transfer of active intermediates and have been recognized as "an area poised for further development". He developed a catalytic insertion reaction of carbene into B?H bond, which contains a critical hydrogen atom transfer process and provide "an attractive approach to chiral organoborons". Moreover, he also developed various efficient transition-metal catalysts for the hydrogenation and hydrosilylation, which contain metal-hydride transfers as key steps and have been used for preparing bioactive compounds.