黄有 教授,博士生导师

Prof. Dr. You Huang

Institute of Elemento-Organic Chemistry and State Key Laboratory of Elemento-organic Chemistry

Nankai University

Weijin Rd. 94, Tianjin 300071

P. R. CHINA

Phone: 86-22-23503159

Fax: 86-22-23503627

E-mail: hyou@nankai.edu.cn

 

IMG_2879

 

EDUCATION:

1994-1997  Department of Chemistry,Zhejiang(Hangzhou) University, Hangzhou, CHINA

           Received Ph.D. degree in June, 1997 (with Prof. Yongmin Zhang).

1986-1989  Department of Chemistry, Henan Normal University, Xinxiang, CHINA. Received

           M. Sc. Degree in June, 1989

1982-1986  Department of Chemistry, Henan Normal University, Xinxiang, CHINA. Received

           B. Sc. Degree in June, 1986

 

ACADEMIC CAREER:

2011-        Professor, State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA.

2008-2011    Professor, Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA.

2002-2008    Associate Professor, Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA.

1999-2002   Postdoctoral associate, Graduate School of Pharmaceutical Sciences,  

            Osaka University, Osaka, Japan. (with Professor Hidenobu Ohmori and Hatsuo

            Maeda)

1997-1999    Postdoctoral associate, Institute of Elemento-organic Chemistry, Nankai University, Tianjin, CHINA. (with Professor Ruyu Chen).

1989-1994    Assistant professor and Lecturer, Department of Chemistry, Henan Normal University, Xinxiang, CHINA.

 

RESEARCH AREAS:

(1)  Organophosphorus Chemistry .

(2)  Organic Synthetic Chemistry

(3)  Heteroatom Organic Chemistry  

 

GROUP MEMBERS:

在读博士研究生: 梁玲,张庆龙,贾鹏昊

在读硕士研究生: 常美佳, 金红星, 吴成洲,冯佳旭, 陈俊龙, 殷仲墨

在读本科生:李宁

已毕业研究生:

博士:孟祥太(2009)解沛忠(2013)郑洁(2014 李二庆(2015 董雪林(2015

硕士:冯德鑫(2004)谷迎春、王金亮(2006)于雅琴(2007)徐大振(2008)张葵、崔萌(2009)赵红霞、邵永臣(2010)马俭泽、熊琴平(2011)王利叶、杨丽华(2012 胡冲冲(2013)高飞(2014)杨杰(2015

本科生:徐大振(2004)潘璐,邹官军(2005)赵红霞(2006)韩百亮,何东明(2007)刘堂林(2008)来文庆,陈羽琛(2010)耿志帅(2012)陈凯宏(2013)郑彦明(2015

在研项目:

1.           国家自然科学基金(21472097)  2015.1-2018.12

有机膦催化的分子间连续环化Domino反应构筑双环 [m. n. 0]骨架

2.           国家自然科学基金(211721152012.1-2015.12

有机膦小分子催化的活泼共轭二烯基于Rauhut-Currier反应的串联反应研究

3.           博士点基金(201200311100022013.1-2015.12

有机膦小分子催化的基于βγ-不饱和α 酮酸酯Domino 反应研究

4.           天津市自然科学基金 (15JCYBJC20000) 2015.4-2018.3

有机膦催化的多环体系的高效构筑方法研究  

 

RECENT PUBLICATIONS:

1   Highly Enantioselective Intermolecular Cross RauhutCurrier Reaction Catalyzed by a Multifunctional Lewis Base Catalyst

Xuelin Dong, Ling Liang, Erqing Li, and You Huang*

Angew. Chem. Int. Ed. 2015, 54, 1621-1624. Hot Paper)

2   Divergent Phosphine-Catalyzed [2+4] or [3+2] Cycloaddition Reactions ofγ-Substituted Allenoates with Oxadienes

Erqing Li, Meijia Chang, Ling Liang, and You Huang*

Eur. J. Org. Chem. 2015, 710–714. Hot Paper)

3   A Sulfur Ylides-Mediated Domino Benzannulation Strategy to Construct Biaryls, Alkenylated   

   and Alkynylated Benzene Derivatives

Gao Fei and Huang, You*

Adv. Synth. Catal. 2014, 356, 2422-2428.

4   Phosphine-Catalyzed Sequential Annulation Domino Reaction: Rapid Construction of Bicyclo[4.1.0]heptene Skeletons

Zheng, Jie; Huang, You* Li Zhengming

Chem. Commun., 2014, 50(43), 5710-5713

5   Phosphine-catalyzed Domino Reaction: A Novel Sequential [2+3] and [3+2] Annulation

Reaction of γ-Substituent Allenoates to Construct Bicyclic[3, 3, 0]octene Derivatives.

Li, Erqing; Huang, You* 

Chem. Commun., 2014, 50 (8), 948-950.

6   Sequential Catalyst Phosphine/Secondary Amine-Promoted [1+4]/ Rearrangement Domino Reaction for the Construction of (2H)-Pyrans and 2-oxabicyclo[2.2.2]oct-5-ene Skeletons

Xie, Peizhong; Yang, Jie; Zheng, Jie; Huang, You* 

Eur. J. Org. Chem., 2014, 6,1189-1194.

7   Phosphine-Catalyzed Domino Reaction: A Novel Method Access to Functionalized

Bicyclic Skeletons  

Li, Erqing; Huang, You* 

Chem. Eur. J., 2014, 20, 3520 

8   Phosphine Initiated Domino Reaction: A Convenient Method for the Preparation of Spiro-cyclopentanones

Liang, Ling; Li, Erqing; Xie, Peizhong; Huang You*

Chem. Asian J. 2014, 9(5), 1270-1273

9   Phosphine-Catalyzed Sequential [2 +3] and [3 + 2] Annulation Domino Reaction of γ- Benzyl Substituted Allenoates with α,β-Unsaturated Ketimines To Construct Aza-bicyclo[3, 3, 0]octane Derivatives

Li, Erqing; Jia, Penghao; Liang, Ling; Huang, You*

ACS Catal. 2014, 4, 600−603.

 

10   A simple and highly efficient procedure for construction of quaternary carbons centers by tributylphosphine catalyzed bis-Michael addition

Xu, Da-Zen; Zhan, Ming-Zhe; Huang, You* 

Tetrahedron 2014, 70(2), 176-180

11.   One step Synthesis of Benzoxazepine Derivatives via a PPh3 Catalyze aza-MBH Domino

Reaction between Salicyl N-tosylimines and Allenoates.

     Zhao, Hongxia; Meng, Xiangtai; Huang, You*

Chem. Commun., 2013, 49(89), 10513-10515.

(Highlighted by Prof. Snieckus, V and Guimarães, K. G. in Synfacts 2014, 10(1), 0027)

12.   Phosphine-Catalyzed Domino Reaction: An Efficient Method for the Synthesis of

 Bicyclo[3.2.0]heptenes Skeleton.

     Zheng, Jie; Huang, You*; Li, Zhengming 

Org. Lett. 2013, 15(22), 5758-5761.

13   Phosphine-Catalyzed Domino Benzannulation: An Efficient Method to Construct Biaryl

Skeletons.

     Zheng, Jie; Huang, You*; Li, Zhengming 

Org. Lett. 2013,  15(19), 5064-5067.

14.  Phosphine-Catalyzed [4+2] Annulation of gamma-Substituent Allenoates: Facile Access to

Functionalized Spirocyclic Skeletons. 

     Li, Erqing; Huang, You*; Liang, Ling; Xie Peizhong 

Org. Lett. 2013,  15(12), 3138-3141.

15.   Tunable Phosphine-Mediated Domino Reaction: Selective Synthesis of 2,3-Dihydrofurans

and Biaryls

     Xie, Peizhong; Li, Erqing; Zheng, Jie; Li, Xin; Huang, You*; Chen, Ruyu 

Adv. Synth. Catal. 2013, 355(1), 161 – 169. Hot Paper)

16.   Tuning Catalysts to Tune the Products: Phosphine-Catalyzed Aza-Michael Addition

Reaction of Hydrazones with Allenoates.

Li, Erqing; Xie, Peizhong; Yang, Lihua, Liang Ling, Huang You*. 

     Chem. Asian J. 2013, 8(3) , 603-610.

17.   Phosphine-Catalyzed Rauhut-Currier Domino Reaction: A Facile Strategy for the

Construction of Carbocyclic Spirooxindoles Skeletons

Hu, Chongchong; Zhang, Qinglong; Huang, You* 

     Chem. Asian J. 2013, 8(9) , 1981-1984

18.   Domino Cyclization Initiated by Cross-Rauhut-Currier Reactions

Xie, Peizhong; Huang, You*

     Eur. J. Org. Chem. 2013, (20), 6213–6226.

 

19.   Sulfur Ylides Participating Domino Cyclization Reaction.

      Li Gongchun; Wang Liye; Huang You*

Chin. J.Org. Chem. 2013, 33(9), 1900-1918.

 

20.   Phosphine-catalyzed Domino Reaction: an Efficient Method for the Synthesis of  

      Highly Functionalized Spirooxazolines.

Yang, Lihua; Xie, Peizhong; Li, Erqing; Li, Xin; Huang, You*; Chen, Ruyu 

      Org. Biomol. Chem. 2012, 10(37), 7628-7634.

21.   Phosphine-Catalyzed Rauhut-Currier Domino Reaction: A Facile Strategy for the   

     Construction of Highly Functionalized Cyclopentene.

Hu, Chongchong; Geng, Zhishuai; Ma, Jianze; Huang, You*; Chen, Ruyu 

    Chem. Asian J. 2012, 7(9) , 2032-2035.                         

22.  Phosphine-mediated Domino Benzannulation Strategy for the Construction of Highly

Functionally Multi-aryl Skeletons   

     Xie, Peizhong; Huang, You*; Chen, Ruyu 

Chem. Eur. J. 2012, 18(24), 7362-7366 (Most  accessed article 2012.5)

 

 

23.   Phosphine-Catalyzed Domino Reaction for the Synthesis of Conjugated 2,3-Dihydrofurans from Allenoates and Nazarov Reagents and the Mechanism Investigation

Xie, Peizhong; Lai, Wenqing; Geng Zhishuai; Huang, You*; Chen, Ruyu

Chem. Asian J. 2012, 7(7) , 1533-1537

24.   Bifunctional phosphine-catalyzed Cross-Rauhut-Currier/Michael/Aldol Condensation Triple Domino Reaction: Synthesis of Functionalized Cyclohexenes.

Xie, Peizhong; Huang, You*; Lai, Wenqing; Meng, Xiangtai; Chen, Ruyu.

Org. Biomol. Chem. 2011, 9(19), 6707-6714.

25. Domino Reaction for the Chemo- and Stereoselective Synthesis of Trans-2,3-Dihydrobenzofurans from N-Thiophosphinyl Iimines and Sulfur Ylides.

Xie, Peizhong; Wang, Liye; Yang, Lihua; Li, Erqing; Ma, Jianze; Huang, You*; Chen, Ruyu.

J. Org. Chem. 2011, 76(19), 7699-7705

26.  Substrate-Controlled Phosphine-Catalyzed Domino Reactions of Activated Conjugated Dienes: Highly  Diastereoselective Synthesis of Bicyclic Skeletons.

Ma, Jianze; Xie, Peizhong; Hu, Chongchong; Huang, You*; Chen, Ruyu.

Chem. Eur. J. 2011, 17(27), 7418-7422 Hot Paper)

27.   N-Heterocyclic Carbene-Catalyzed (NHC) Three-Component Domino Reactions: Highly

Stereoselective  Synthesis of Functionalized Acyclic ε-Ketoesters.

Ma, Jianze; Huang, You*; Chen, Ruyu.

Org. Biomol. Chem. 2011, 9(6), 1791-1798

28.  Phosphine-Catalyzed Domino Reaction: Highly Stereoselective  Ssynthesis of Trans-2,3-Dihydrobenzofurans  from Salicyl  N-Thiophosphinyl Imines and Allylic Carbonates.

Xie, Peizhong; Huang, You*; Chen, Ruyu.

Org Lett. 2010, 12(17), 3768-3771.

29.   PPh3-Catalyzed Domino Reaction: A Facile Method for the  Synthesis of Chroman Derivatives.

Meng, Xiangtai; Huang, You*; Zhao, Hongxia; Xie, Peizhong; Ma, Jianze; Chen, Ruyu.

Org. Lett. 2009, 11(4), 991-994.

30.   Bifunctional Phosphine-Catalyzed Domino Reaction: Highly Stereoselective Synthesis of cis-2,3-Dihydrobenzofurans  from Salicyl N-Thiophosphinyl Imines and Allenes.

Meng, Xiangtai; Huang, You*; Chen, Ruyu.

Org Lett. 2009, 11(1), 137-140.

 

31.   A Novel Selective aza-Morita-Baylis-Hillman (aza-MBH)  Domino Reaction and aza-MBH Reaction of N-Sulfonated Imines with Acrolein Catalyzed by a Bifunctional Phosphine Organocatalyst.

Meng, Xiangtai; Huang, You*; Chen, Ruyu.

Chem. Eur. J. 2008, 14(23), 6852-6856.Hot Paper Most accessed article 2008.7)