轩维民
轩维民
博士 研究员
轩维民,博士,研究员,元素有机化学研究所,毕业于美国新墨西哥大学,河北省玉田县人。
工作内容:教学科研
人才称号:天津市级青年学术带头人
通讯地址:天津市卫津路94号南开大学天南大联合楼D座404

电 话:

电子邮件:wxuan@nankai.edu.cn

课题组网站:
研究领域:

基因密码子扩展

生物探针

蛋白质修饰

大分子药物开发

教育及科研经历:

2003-2007年 天津大学药学院本科

2009-2013年 新墨西哥大学化学系博士(导师:Wei Wang)

2013-2017年 斯克利普斯研究所博士后(导师:Peter G. Schultz)

荣誉和奖励

科研成果与代表作

1.Xuan, W.;§ Yao, A.;§ Schultz PG. Genetically encoded fluorescent probe for detecting sirtuins in living cells. J. Am. Chem. Soc., 2017, 139 (36), pp 12350–12353.

2.Xuan, W.; Schultz, PG. A Strategy for Creating Organisms Dependent on Noncanonical Amino Acids. Angew. Chem. Int. Ed. 2017, 56, 9170-9173. 

3.Xuan, W.; Shao, S.; Schultz, PG. Protein Crosslinking by Genetically Encoded Noncanonical Amino Acids with Aryl Carbamate Side Chains. Angew. Chem. Int. Ed. (hot paper) 2017, 56, 5096 –5100.

4.Xuan, W.; Li, J.; Luo, X.; Schultz, PG. Genetic Incorporation of a Reactive Isothiocyanate Group into Proteins. Angew. Chem. Int. Ed. 2016, 55, 10065-10068.

5.Xuan, W.; § Pan, R. § (equal contribution); Wei Y.; Cao, Y.; Li, H.; Liang, FS.; Liu, K.; Wang, W. Reaction-based “off-on” Fluorescent Probe Enabling Detection of Endogenous Labile Fe2+ and Imaging of Zn2+- induced Fe2+ Flux in Living Cells and Elevated Fe2+ in Ischemic Stroke. Bioconjugate Chem., 2016, 27, 302?308. 

6.Xiao, H.;§ Xuan, W.§ (equal contribution); Shao, S.; Liu, T.; Schultz, P. G. Genetic Incorporation of ε-N-2-Hydroxyisobutyryl-lysine into Recombinant Histones. ACS Chem. Biol. 2015, 10, 1599?1603.

7.Xuan, W.; Cao, Y; Zhou, J.; Wang, W. A FRET-based ratiometric fluorescent and colorimetric probe for facile detection of organophosphonate nerve agent mimic DCP. Chem. Commun., 2013, 49, 10474—10476.

8.Xuan, W.; Pan, R.; Cao, Y.; Liu, K.; Wang, W. A fluorescent probe capable of detecting H2S at submicromolar concentrations in cells. Chem. Commun., 2012, 48, 10669-10671.

9.Xuan, W.; Chen, C.; Cao. Y.; He, W.; Jiang, W.; Liu, K.; Wang, W. Rational design of a ratiometric fluorescent probe with a large emission shift for the facile detection of Hg2+. Chem. Commun., 2012, 48, 7292–7294. 

10.Xuan, W.; Sheng, C.; Cao, Y.; He, W.; Wang, W. Fluorescent Probes for the Detection of Hydrogen Sulfide in Biological Systems (highlights). Angew. Chem. Int. Ed. 2012, 51, 2282 – 2284.

人才培养
实验室长期招收硕士生和博士生。
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