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熊虎
2019-09-09  

熊虎

南开大学百青

学科专业
分析化学
通讯地址
天津市南开区卫津路94号南开大学化学楼南楼103室
联系电话
电子邮件
xionghu@nankai.edu.cn
网站地址
研究领域
近红外一区/二区荧光成像,生物自发荧光成像,光声成像,光热治疗,光动力治疗





教育及科研经历
2005年-2009年,郑州大学,化学学士
2009年-2014年,中科院上海有机化学研究所,有机化学博士,导师:唐勇院士与谢作伟院士
2014年-2018年,美国德州大学西南医学中心,博士后,合作导师:Daniel J. Siegwart
2018年12月-至今,南开大学,分析科学研究中心,特聘研究员





荣誉和奖励
科研成果与代表作
代表作:
(15) Elkassih, S. A., Kos, P., Xiong, H., Siegwart, D. J.* Degradable redox-responsive disulfide-based nanogel drug carriers via dithiol oxidation polymerization. Biomaterials Science, 2019, 7, 607-617.
(14) Xiong, H., Zhou, K., Yan, Y., Miller, J. B., Siegwart, D. J.* Tumor activated water-soluble photosensitizers for near-infrared photodynamic cancer therapy. ACS Applied Materials & Interfaces, 2018, 10, 16335-16343.
(13) Yan, Y., Xiong, H., Zhang, X., Cheng, Q., Siegwart, D. J.* Systemic mRNA delivery to the lungs by functional polyester-based carriers. Biomacromolecules, 2017, 18, 4307-4315.
(12) Xiong, H., Zuo, H., Yan, Y., Occhialini, G., Zhou, K., Wan, Y., Siegwart, D. J.* High-contrast fluorescence detection of metastatic breast cancer including bone and liver micrometastases via size-controlled pH-activatable water-soluble probes. Advanced Materials, 2017, 29, 1700131.
(11) Miller, J. B., Zhang, S., Kos, P., Xiong, H., Zhou, K., Perelman, S. S., Zhu, H., Siegwart, D. J.* Non-viral CRISPR/Cas gene editing in vitro and in vivo enabled by synthetic nanoparticle co-delivery of Cas9 mRNA and sgRNA. Angew. Chem. Int. Ed. 2017, 56, 1059-1063.
(10) Feng, L.-W., Ren, H., Xiong, H., Wang, P., Wang, L., Tang, Y.* Reaction of Donor-Acceptor Cyclobutanes with Indoles: A General Protocol for the Formal Total Synthesis of (±)-Strychnine and the Total Synthesis of (±)-Akuammicine. Angew. Chem. Int. Ed. 2017, 129, 3101-3104.
(9) Chen, P., Zuo, H., Xiong, H., Kolar, M. J., Chu, Q., Saghatelian, A., Siegwart, D. J., Wan, Y.* Gpr132 Sensing of Lactate Mediates Tumor-Macrophage Interplay to Promote Breast Cancer Metastasis. Proc. Natl. Acad. Sci. U. S. A. 2017, 114, 580-585.
(8) Yan, Y., Zhou, K., Xiong, H., Miller, J. B., Motea, E. A., Boothman, D. A., Liu, L.*, Siegwart, D. J.* Aerosol delivery of stabilized polyester-siRNA nanoparticles to silence gene expression in orthotopic lung tumors. Biomaterials, 2017, 118, 84-93.
(7) Yan, Y., Liu, L., Xiong, H., Miller, J. B., Zhou, K., Kos, P., Huffman, K. E., Elkassih, S., Norman, J. W., Carstens, R., Kim, J., Minna, J. D., Siegwart, D. J.* Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cells. Proc. Natl. Acad. Sci. U. S. A. 2016, 113, 5702-5710.
(6) Xiong, H., Kos, P., Yan, Y., Zhou, K., Miller, J. B., Elkassih, S., Siegwart, D. J.* Activatable water-soluble probes enhance tumor imaging by responding to dysregulated pH and exhibiting high tumor-to-liver fluorescence emission contrast. Bioconjugate Chemistry, 2016, 27, 1737-1744.
(5) Zhou, K., Nguyen, L. H., Miller, J. B., Yan, Y., Kos, P., Xiong, H., Li, L., Hao, J., Minnig, J. T., Zhu, H., Siegwart, D. J.* Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model. Proc. Natl. Acad. Sci. U. S. A. 2016, 113, 520-525.
(4) Hao, J., Kos, P., Zhou, K., Miller, J. B., Xue, L., Yan, Y., Xiong, H., Elkassih, S., Siegwart, D. J.* Rapid synthesis of a lipocationic polyester library via ring-opening polymerization of functional valerolactones for efficacious siRNA delivery. J. Am. Chem. Soc. 2015, 137, 9206-9209.
(3) Xiong, H., Xu, H., Liao, S., Xie, Z.*, Tang, Y.* Copper-Catalyzed Highly Enantioselective Cyclopentannulation of Indoles with Donor-Acceptor Cyclopropanes. J. Am. Chem. Soc. 2013, 135, 7851-7854. (Highlighted in SYNFORM 2013, 10, 122.)
(2) Xu, H., Qu, J.-P., Liao, S., Xiong, H., Tang, Y.* Highly Enantioselective [3+2] Annulation of Cyclic Enol Silyl Ethers with Donor–Acceptor Cyclopropanes: Accessing 3a-Hydroxy [n.3.0] Carbobicycles. Angew. Chem. Int. Ed. 2013, 52, 4004-4007.
(1) Li, J., Liao, S.-H., Xiong, H., Zhou, Y.-Y., Sun, X.-L., Zhang, Y., Zhou, X.-G., Tang, Y.* Highly Diastereo- and Enantioselective Cyclopropanation of 1,2-Disubstituted Alkenes. Angew. Chem. Int. Ed. 2012, 51, 8838-8841.




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