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轩维民
2019-09-09  

轩维民

学科专业
化学生物学
通讯地址
天津市卫津路94号天南大联合楼D座404
联系电话
电子邮件
wxuan@nankai.edu.cn
网站地址
研究领域
基因密码子扩展
生物探针
蛋白质修饰
大分子药物开发


教育及科研经历
2003-2007年 天津大学药学院本科
2009-2013年 新墨西哥大学化学系博士(导师:Wei Wang)
2013-2017年 斯克利普斯研究所博士后(导师:Peter G. Schultz)


荣誉和奖励
科研成果与代表作
1.Xuan, W.;§ Yao, A.;§ Schultz PG. Genetically encoded fluorescent probe for detecting sirtuins in living cells. J. Am. Chem. Soc., 2017, 139 (36), pp 12350–12353.
2.Xuan, W.; Schultz, PG. A Strategy for Creating Organisms Dependent on Noncanonical Amino Acids. Angew. Chem. Int. Ed. 2017, 56, 9170-9173.
3.Xuan, W.; Shao, S.; Schultz, PG. Protein Crosslinking by Genetically Encoded Noncanonical Amino Acids with Aryl Carbamate Side Chains. Angew. Chem. Int. Ed. (hot paper) 2017, 56, 5096 –5100.
4.Xuan, W.; Li, J.; Luo, X.; Schultz, PG. Genetic Incorporation of a Reactive Isothiocyanate Group into Proteins. Angew. Chem. Int. Ed. 2016, 55, 10065-10068.
5.Xuan, W.; § Pan, R. § (equal contribution); Wei Y.; Cao, Y.; Li, H.; Liang, FS.; Liu, K.; Wang, W. Reaction-based “off-on” Fluorescent Probe Enabling Detection of Endogenous Labile Fe2+ and Imaging of Zn2+- induced Fe2+ Flux in Living Cells and Elevated Fe2+ in Ischemic Stroke. Bioconjugate Chem., 2016, 27, 302?308.
6.Xiao, H.;§ Xuan, W.§ (equal contribution); Shao, S.; Liu, T.; Schultz, P. G. Genetic Incorporation of ε-N-2-Hydroxyisobutyryl-lysine into Recombinant Histones. ACS Chem. Biol. 2015, 10, 1599?1603.
7.Xuan, W.; Cao, Y; Zhou, J.; Wang, W. A FRET-based ratiometric fluorescent and colorimetric probe for facile detection of organophosphonate nerve agent mimic DCP. Chem. Commun., 2013, 49, 10474—10476.
8.Xuan, W.; Pan, R.; Cao, Y.; Liu, K.; Wang, W. A fluorescent probe capable of detecting H2S at submicromolar concentrations in cells. Chem. Commun., 2012, 48, 10669-10671.
9.Xuan, W.; Chen, C.; Cao. Y.; He, W.; Jiang, W.; Liu, K.; Wang, W. Rational design of a ratiometric fluorescent probe with a large emission shift for the facile detection of Hg2+. Chem. Commun., 2012, 48, 7292–7294.
10.Xuan, W.; Sheng, C.; Cao, Y.; He, W.; Wang, W. Fluorescent Probes for the Detection of Hydrogen Sulfide in Biological Systems (highlights). Angew. Chem. Int. Ed. 2012, 51, 2282 – 2284.



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