研究方向：

1.有机磷化学

2.有机合成化学

3.杂原子有机化学

在研项目：

1.新型多官能团有机膦催化剂的设计、合成以及在对映选择性的Rauhut–Currier相关反应中的应用

国家自然科学基金（21672109）

2017.1-2020.12

2.有机膦催化的分子间连续环化Domino反应构筑双环 [m. n. 0]骨架 

国家自然科学基金(21472097) 

2015.1-2018.12

3.有机膦催化的多环体系的高效构筑方法研究

天津市自然科学基金 (15JCYBJC20000)

2015.4-2018.3

1982-1986年 河南师范大学化学系 本科

1986-1989年 河南师范大学化学系 硕士研究生 

1994-1997年 浙江大学化学系 博士研究生

1989-1994年 河南师范大学化学系 助教、讲师

1997-1999年 南开大学元素所 博士后

1999-2002年 大阪大学药学院 博士后

2002-2008年 南开大学化学院 副教授

2008-2011年 南开大学化学院 教授

2011年至今 南开大学化学院 教授，博士生导师

2004年，获南开大学敬业奖教金教学二等奖

2013年，获南开大学敬业奖教金教学二等奖

2013年，获南开大学校级“教工先锋岗”先进个人

2013年，获南开大学第五届“良师益友”提名奖

代表性论文：

1 Sequential [1+4]- and [2+3]-Annulation of Prop-2-ynylsulfonium Salts: Access to Hexahydropyrrolo[3,2-b]indoles

Jia, Penghao; Zhang, Qinglong; Ou, Qima and Huang You* 

Org. Lett., 2017, 19, 4664-4667.

2 Divergent Synthesis of Hydropyridine Derivatives via Nitrogen Containing Lewis Base Mediated Regioselective [4+2] Cyclizations

Jin, Hongxing; Li, Erqing and Huang You* 

Org. Chem. Front., 2017, 4, Doi: 10.1039/C7QO00596B.

3 Phosphine-Catalyzed Intramolecular Rauhut-Currier Reaction: Enantioselective Synthesis of Hydro-2H-Indole Derivatives

Jin, Hongxing; Zhang, Qinglong; Li, Erqing; Jia, Penghao; Li, Ning and Huang You* 

Org. Biomol. Chem. 2017, 15, 7097-7101.

4 Phosphine-Mediated Sequential Annulation Reaction: Access to Functionalized Benzofurans and 4,5-Dihydrobenzofurans

Liang, Ling; Dong, Xuelin and Huang You* 

Chem. Eur. J., 2017, 23, 7882-7886.（Hot Paper)

5 A phosphine mediated sequential annulation process of 2-tosylaminochalcones with MBH carbonates to construct functionalized aza-benzobicyclo [4.3.0] derivates

Zhang, Qinglong; Zhu, Yannan; Jin, Hongxing and Huang You* 

Chem. Commun., 2017, 53, 3974-3977.

6 [3 + 2]-Annulation of Prop-2-ynylsulfonium Salts: Access to Hydroindol-5-ones Containing a Methylthio Group

Jia, Penghao; Zhang, Qinglong; Jin, Hongxing and Huang You* 

Org. Lett. 2017, 19, 412-415.

7 Bifunctional Phosphine Catalyzed Sequential Annulations of Allenoates and Ketimines: Construction of Functionalized Poly-heterocycle Rings

Li, Erqing; Jin,Hongxing; Jia, Penghao; Dong, Xuelin and Huang You* 

Angew. Chem. Int. Ed. 2016, 55 (38), 11591-11594 DOI:10.1002/anie.201605189). 

8. Sequential Annulations Domino Reaction of Sulfur Ylides and ???-Unsaturated Cyclic Ketimines: Synthesis of Cyclic 2-Alkenyl Aziridines 

Jia, Penghao and Huang You* 

Org. Lett. 2016, 18(10), 2475-2478.

9 Phosphine-Catalyzed [3 + 3]-Domino Cycloaddition of Ynones and Azomethine Imines To Construct Functionalized Hydropyridazine Derivatives

Liang, Ling and Huang You* 

Org. Lett. 2016, 18(11), 2604-2607.

10 One-Pot Synthesis of Polysubstituted Benzenes through a N,N-dimethyl-4-aminopyridine (DMAP)-Catalyzed [4+2] Benzannulation of 1,3-Bis(sulfonyl)butadienes and g-Substituted Allenoates

Chang, Meijia; Wu, Chengzhou; Zheng, Jie and Huang You* 

Chem. Asian J. 2016, 11(5), 1512-1517（Hot Paper) 

11 DABCO-Mediated [4 + 4]-Domino Annulation: Access to Functionalized Eight-Membered Cyclic Ethers

Liang, Ling; Li, Erqing; Dong, Xuelin and Huang You* 

Org. Lett. 2015, 17(19), 4914?4917. 

12 Highly Enantioselective Intermolecular Cross Rauhut–Currier Reaction Catalyzed by a Multifunctional Lewis Base Catalyst 

Dong, Xuelin; Liang, Ling; Li, Erqing and Huang You* 

Angew. Chem. Int. Ed. 2015, 54, 1621-1624. （Hot Paper）

13 Divergent Phosphine-Catalyzed [2+4] or [3+2] Cycloaddition Reactions ofγ-Substituted Allenoates with Oxadienes

Li, Erqing; Chang, Meijia; Liang, Ling and Huang You* 

Eur. J. Org. Chem. 2015, 710–714. （Hot Paper)

14. Morita–Baylis–Hillman adduct derivatives (MBHADs): versatile reactivity in Lewis base-promoted annulation

Xie, Peizhong and Huang You* 

Org. Biomol. Chem. 2015, 13(32), 8578–8595

15. A Sulfur Ylides-Mediated Domino Benzannulation Strategy to Construct Biaryls, Alkenylated and Alkynylated Benzene Derivatives

Gao Fei and Huang You* 

Adv. Synth. Catal. 2014, 356, 2422-2428.

16 Phosphine-catalyzed Domino Reaction: A Novel Sequential [2+3] and [3+2] Annulation Reaction of γ-Substituent Allenoates to Construct Bicyclic[3, 3, 0]octene Derivatives. 

Li, Erqing; Huang, You* 

Chem. Commun., 2014, 50 (8), 948-950.

17 Sequential Catalyst Phosphine/Secondary Amine-Promoted [1+4]/ Rearrangement Domino Reaction for the Construction of (2H)-Pyrans and 2-oxabicyclo[2.2.2]oct-5-ene Skeletons 

Xie, Peizhong; Yang, Jie; Zheng, Jie; Huang, You* 

Eur. J. Org. Chem., 2014, 1189-1194.

18 Phosphine-Catalyzed Domino Reaction: A Novel Method Access to Functionalized 

Bicyclic Skeletons 

Li, Erqing; Huang, You* 

Chem. Eur. J., 2014, 20, 3520 

19 Phosphine Initiated Domino Reaction: A Convenient Method for the Preparation of Spiro-cyclopentanones 

Liang, Ling; Li, Erqing; Xie, Peizhong; Huang You*

Chem. Asian J. 2014, 9(5), 1270-1273

20 Phosphine-Catalyzed Sequential [2 +3] and [3 + 2] Annulation Domino Reaction of γ- Benzyl Substituted Allenoates with α,β-Unsaturated Ketimines To Construct Aza-bicyclo[3, 3, 0]octane Derivatives 

Li, Erqing; Jia, Penghao; Liang, Ling; Huang, You* 

ACS Catal. 2014, 4, 600?603.

21 A simple and highly efficient procedure for construction of quaternary carbons centers by tributylphosphine catalyzed bis-Michael addition 

Xu, Da-Zen; Zhan, Ming-Zhe; Huang, You* 

Tetrahedron 2014, 70, 176-180

22 One step Synthesis of Benzoxazepine Derivatives via a PPh3 Catalyze aza-MBH Domino Reaction between Salicyl N-tosylimines and Allenoates.

Zhao, Hongxia; Meng, Xiangtai; Huang, You*

Chem. Commun., 2013, 49(89), 10513-10515. 

(Highlighted by Prof. Snieckus, V and Guimar?es, K. G. in Synfacts 2014, 10(1), 0027)

23 Phosphine-Catalyzed Domino Reaction: An Efficient Method for the Synthesis of Bicyclo[3.2.0]heptenes Skeleton.

Zheng, Jie; Huang, You*; Li, Zhengming 

Org. Lett. 2013, 15(22), 5758-5761.

24. Phosphine-Catalyzed Domino Benzannulation: An Efficient Method to Construct Biaryl Skeletons.

Zheng, Jie; Huang, You*; Li, Zhengming 

Org. Lett. 2013, 15(19), 5064-5067.

25. Phosphine-Catalyzed [4+2] Annulation of gamma-Substituent Allenoates: Facile Access to 

Functionalized Spirocyclic Skeletons. 

Li, Erqing; Huang, You*; Liang, Ling; Xie Peizhong 

Org. Lett. 2013, 15(12), 3138-3141.

26. Tunable Phosphine-Mediated Domino Reaction: Selective Synthesis of 2,3-Dihydrofurans and Biaryls 

Xie, Peizhong; Li, Erqing; Zheng, Jie; Li, Xin; Huang, You*; Chen, Ruyu 

Adv. Synth. Catal. 2013, 355(1), 161 – 169. （Hot Paper) 

27. Tuning Catalysts to Tune the Products: Phosphine-Catalyzed Aza-Michael Addition Reaction of Hydrazones with Allenoates. 

Li, Erqing; Xie, Peizhong; Yang, Lihua, Liang Ling, Huang You*. 

Chem. Asian J. 2013, 8(3) , 603-610.

28. Phosphine-Catalyzed Rauhut-Currier Domino Reaction: A Facile Strategy for the Construction of Carbocyclic Spirooxindoles Skeletons 

Hu, Chongchong; Zhang, Qinglong; Huang, You* 

Chem. Asian J. 2013, 8(9) , 1981-1984 

29. Domino Cyclization Initiated by Cross-Rauhut-Currier Reactions

Xie, Peizhong; Huang, You*

Eur. J. Org. Chem. 2013, (20), 6213–6226.

30. Sulfur Ylides Participating Domino Cyclization Reaction.

Li Gongchun; Wang Liye; Huang You* 

Chin. J. Chem. 2013, 33(9), 1900-1918.

31. Phosphine-catalyzed Domino Reaction: an Efficient Method for the Synthesis of Highly Functionalized Spirooxazolines. 

Yang, Lihua; Xie, Peizhong; Li, Erqing; Li, Xin; Huang, You*; Chen, Ruyu 

Org. Biomol. Chem. 2012, 10(37), 7628-7634.

32. Phosphine-Catalyzed Rauhut-Currier Domino Reaction: A Facile Strategy for the Construction of Highly Functionalized Cyclopentene.

Hu, Chongchong; Geng, Zhishuai; Ma, Jianze; Huang, You*; Chen, Ruyu 

Chem. Asian J. 2012, 7(9) , 2032-2035.

33. Phosphine-mediated Domino Benzannulation Strategy for the Construction of Highly Functionally Multi-aryl Skeletons 

Xie, Peizhong; Huang, You*; Chen, Ruyu 

Chem. Eur. J. 2012, 18(24), 7362-7366 (Most accessed article 2012.5) 

34. Phosphine-Catalyzed Domino Reaction for the Synthesis of Conjugated 2,3-Dihydrofurans from Allenoates and Nazarov Reagents and the Mechanism Investigation

Xie, Peizhong; Lai, Wenqing; Geng Zhishuai; Huang, You*; Chen, Ruyu

Chem. Asian J. 2012, 7(7) , 1533-1537 

35. Bifunctional phosphine-catalyzed Cross-Rauhut-Currier/Michael/Aldol Condensation Triple Domino Reaction: Synthesis of Functionalized cyclohexenes. 

Xie, Peizhong; Huang, You*; Lai, Wenqing; Meng, Xiangtai; Chen, Ruyu.

Org. Biomol. Chem. 2011, 9(19), 6707-6714. 

36. Domino Reaction for the Chemo- and Stereoselective Synthesis of Trans-2,3-Dihydrobenzofurans from N-Thiophosphinyl Iimines and Sulfur Ylides. 

Xie, Peizhong; Wang, Liye; Yang, Lihua; Li, Erqing; Ma, Jianze; Huang, You*; Chen, Ruyu.

J. Org. Chem. 2011, 76(19), 7699-7705 

37. Substrate-Controlled Phosphine-Catalyzed Domino Reactions of Activated Conjugated Dienes: Highly Diastereoselective Synthesis of Bicyclic Skeletons. 

Ma, Jianze; Xie, Peizhong; Hu, Chongchong; Huang, You*; Chen, Ruyu.

Chem. Eur. J. 2011, 17(27), 7418-7422 （Hot Paper) 

38. N-Heterocyclic Carbene-Catalyzed (NHC) Three-Component Domino Reactions: Highly 

Stereoselective Synthesis of Functionalized Acyclic ε-Ketoesters. 

Ma, Jianze; Huang, You*; Chen, Ruyu.

Org. Biomol. Chem. 2011, 9(6), 1791-1798 

39. Phosphine-Catalyzed Domino Reaction: Highly Stereoselective Ssynthesis of Trans-2,3-Dihydrobenzofurans from Salicyl N-Thiophosphinyl Imines and Allylic Carbonates. 

Xie, Peizhong; Huang, You*; Chen, Ruyu.

Org Lett. 2010, 12(17), 3768-3771. 

40. PPh3-Catalyzed Domino Reaction: A Facile Method for the Synthesis of Chroman Derivatives. 

Meng, Xiangtai; Huang, You*; Zhao, Hongxia; Xie, Peizhong; Ma, Jianze; Chen, Ruyu.

Org. Lett. 2009, 11(4), 991-994. 

41. Bifunctional Phosphine-Catalyzed Domino Reaction: Highly Stereoselective Synthesis of cis-2,3-Dihydrobenzofurans from Salicyl N-Thiophosphinyl Imines and Allenes. 

Meng, Xiangtai; Huang, You*; Chen, Ruyu.

Org Lett. 2009, 11(1), 137-140. 

42. A Novel Selective aza-Morita-Baylis-Hillman (aza-MBH) Domino Reaction and aza-MBH Reaction of N-Sulfonated Imines with Acrolein Catalyzed by a Bifunctional Phosphine Organocatalyst.

Meng, Xiangtai; Huang, You*; Chen, Ruyu.

Chem. Eur. J. 2008, 14(23), 6852-6856.（Hot Paper， Most accessed article 2008.7)

已培养博士生8名，硕士生19名，本科生18名，在读博士生6名，硕士生3名。

在读博士研究生：金红星，李宁，冯佳旭， 陈俊龙，朱晏楠，蔡卫

在读硕士研究生： 周一鸣，王丹，赖镜雄

已毕业研究生：

博士：孟祥太（2009）解沛忠（2013）郑洁（2014） 李二庆（2015） 董雪林（2015） 梁玲（2016）张庆龙（2017）贾鹏昊（2018）

硕士：冯德鑫（2004）谷迎春、王金亮（2006）于雅琴（2007）徐大振（2008）张葵、崔萌（2009）赵红霞、邵永臣（2010）马俭泽、熊琴平（2011）王利叶、杨丽华（2012） 胡冲冲（2013）高飞（2014）杨杰（2015） 常美佳（2016） 吴成洲（2017）殷仲墨（2018）

本科生：徐大振（2004）潘璐，邹官军（2005）赵红霞（2006）韩百亮，何东明（2007）刘堂林（2008）来文庆，陈羽琛（2010）耿志帅（2012）陈凯宏（2013）郑彦明（2015）李宁（2016）张岩（2016）唐庆煊（2017）修文（2017））王丹（2018）朱子琦（2018）