新颖实用的有机合成研究和合成方法的探索； 具有生物活性的天然小分子的合成及其类似物的设计、合成和生物活性研究； 精细化学品合成及工艺研究； 电子产品清洗剂研究。

1986-09至1990-07，北京化工大学，应用化学系，学士

2000-09至2005-06，南开大学，化学学院，博士 

1990-07至2000-08，天津化工厂，工程师

2005-07至2024-12，南开大学，化学学院，副教授

2024-12至现在，南开大学，化学学院，教授

2016-07至2017-07，美国加州大学圣巴巴拉分校，访问学者

主持完成国家自然科学基金面上项目2项，天津市面上项目2项，天津市重点项目1项，并参与多项国家基金项目的研究工作，完成多项精细化工应用项目。研究工作已经发表研究论文40余篇；申请发明专利21项，国际专利3项，其中授权专利14项。部分代表作：

1. J. Y. Zhou, L. H. Chen, Ziang Miao, J. J. Li, Y. X. Luan,* L. Chen,* P. P. Tang*, Photocatalyst-Regulated Trifluoromethoxylation of Aryl Halides under Silver Promotion, J. Am. Chem. Soc., 2025, 147, 38979−38986. 

2. P. F. Yang, S. H. Chen, J. X. Lu, P. F. Ning, W. Q. Zhao, Y. X. Luan, L. Chen,* X. F. Xu,* P. P. Tang*, Silver-Catalyzed syn-Stereoselective Trifluoromethoxylation of Bicyclo[1.1.0]butanes, Org. Lett. 2025, 27, 7679−7684 

3. I. Djavani-Tabrizi, Z. Q. Yuan, T. T. Lindkvist, J. M. Xing, L. Chen,* S. B. Nielsen*, Gas-Phase Fluorescence Excitation Experiments on Cryogenically Cold Rhodamine B Cations Linked to Various Amino Acid Esters, J. Am. Soc. Mass Spectrom. 2025, 36, 409−415. 

4. Catalytic Asymmetric Reactions of Ketimines and Alkenes via [2+2] Cy-cloaddition: Chemical Reactivity Controlled by Switching a Heteroatom, Q. Zhao, Y. Li, Z. Y. Ren, Y. B. Shao, L. Chen*, X. Li*, J. Am. Chem. Soc., 2024, 146, 32088-32097

5. Silver-Enabled Dearomative Trifluoromethoxylation of Indoles, Z. J. Deng, L. D. Meng, X. Bing, S. X. Niu, X. F. Zhang, J. Q. Peng, Y. X. Luan, L. Chen*, P. P. Tang*, J. Am. Chem. Soc., 2024, 146, 2325-2332.

6. Enantioselective Synthesis of “NO2···NH” Hydrogen Bond-Stabilized C–N Axially Chiral Diarylamines, W. Lin, Y. B. Shao, Z. Y. Hao, Z. L. Huang, Z. Y. Ren, L. Chen*, X. Li*, ACS Catalysis, 2024, 14, 1183-1192.

7. Predicting bond dissociation energies of cyclic hypervalent halogen reagents using DFT calculations and graph attention network model, Y. Shao, Z. Ren, Z. Han, L. Chen*, Y. Li*, X. Xue*, Beilstein J. Org. Chem. 2024, 20, 1444–1452.

8. Asymmetric alkenylation reaction of benzoxazinones with diarylethylenes catalyzed by B(C6F5)3/chiral phosphoric acid, Z. Liu, Z. Y. Ren, C. Yang, X. Y. Shao, L. Chen*, X. Li*, Chin. Chem. Lett., 2023, 108939.

9. Asymmetric Synthesis of Axially Chiral Arylpyrazole via an Organocatalytic Arylation Reaction, X. Gao, C. W. Li, L. Chen*, X. Li*, Org. Lett., 2023, 25, 7628- 7632. 

10. Synthesis and Biological Activity of Lycorine Derivatives Containing Malate Ester, Y. Zhao, L. Qiao, G. F. Zhao, L. Chen*, Chem. J. Chinese Uni., 2021, 42, 2789-2797.

11. Triangular rhodamine triads and their intrinsic photophysics revealed from gas-phase ion fluorescence experiments, Zhao, Y., Sørensen, E. R., Lindkvist, T. T., Kjær, C., Nielsen, M. B., Chen, L.*, Nielsen, S. B.* Chem. Eur. J. 2021, 27, 10875–10882.

12. Gas-phase Förster resonance energy transfer in mass-selected ions with methylene or peptide linkers between two dyes: a concerted dance of charges,  Kjær, C.; Zhao, Y.; Stockett, M. H.; Chen, L.*; Hansen, K.; Nielsen, S. B.. Phys. Chem. Chem. Phys, 2020, 22, 11095-11100.

已培养硕士15名。