王宝雷
王宝雷
博士 副研究员
王宝雷,博士,副研究员,元素有机化学研究所,毕业于南开大学,安徽宿县砀山县。
工作内容:教学科研
特殊人才称号:
通讯地址:天津市卫津路94号南开大学元素有机化学研究所六教405室
电 话:18920020912
电子邮件:nkwbl@nankai.edu.cn
课题组网站:
研究领域:有机化学,农药学
教育及科研经历:

2001年在南开大学化学学院元素有机化学研究所攻读农药学专业博士学位,师从李正名院士,2004年7月博士毕业留校任教。2015-2016年受国家公派赴加拿大University of Alberta作访问学者,师从Frederick G. West教授进行环状联烯和Nazarov电环化领域的有机合成方法学研究。任教以来,长期担任南开大学本科生《有机化学》和《有机化学实验》课程的教学工作,并从事新农药创制的基础研究工作。科研工作主要致力于具有生物活性物质的分子设计、有机合成及构效关系研究。曾主持并完成国家自然科学基金、国家重点研发计划子课题、高等学校博士学科点专项科研基金各1项,天津市自然科学基金2项;曾参加国家“863”计划,“973”计划,中澳国际合作项目,国家自然科学(重点)基金,天津大学/南开大学联合项目,美国DOW化学公司以及Aberjona公司的合作研发项目等多个课题的工作。目前主持国家自然科学基金面上项目课题2项。至今已发表论文60篇,申请发明专利15项。现为“Chin. Chem. Lett.”杂志青年编委,“J. Agric. Food Chem.”、“Pest Manag. Sci.”、“Phosphorus Sulfur Silicon Relat. Elem.”、“有机化学”等杂志审稿人。

荣誉和奖励

2012年,浙江省高校优秀科研成果二等奖

科研成果与代表作

部分发表的文章如下:

[35] Huan Li, Hang Liu, Yan Zhang, Na Yang, Lixia Xiong, Zhengming Li, Baolei Wang*. Synthesis, insecticidal activities, and SAR studies of novel piperazine-containing heterocyclic mono-/di-/tri-amide derivatives. Chin. Chem. Lett., 2021, 32, doi: https://doi.org/10.1016/j.cclet.2021.02.002.

[34] Baolei Wang, Marius-Georgian Constantin, Simarpreet Singh, Yuqiao Zhou, Rebecca L. Davis*, F. G. West*. Generation and trapping of electron-deficient 1,2-cyclohexadienes. Unexpected hetero-Diels–Alder reactivity. Org. Biomol. Chem., 2021, 19: 399-405.

[33] Yan Zhang, Junfeng Shang, Huan Li, Hang Liu, Haibin Song, Baolei Wang*, Zhengming Li*. Synthesis of novel N-pyridylpyrazole derivatives containing 1,2,4-oxadiazole moiety via 1,3-dipolar cycloaddition and their structures and biological activities. Chin. Chem. Lett., 2020, 31: 1276-1280.

[32] Baolei Wang*, Hongxue Wang, Hang Liu, Lixia Xiong, Na Yang, Yan Zhang, Zhengming Li*. Synthesis and structure-insecticidal activity relationship of novel phenylpyrazole carboxylic acid derivatives containing fluorine moiety. Chin. Chem. Lett., 2020, 31: 739-745.

[31] Bao-Lei Wang*, Hong-Wei Zhu, Zheng-Ming Li, Xiao Zhang, Shu-Jing Yu, Yi Ma, Hai-Bin Song. One-Pot Synthesis, Structure and Structure-Activity Relationship of Novel Bioactive Diphenyl/Diethyl(3-Bromo-1-(3-Chloropyridin-2-yl)-1H-Pyrazol-5-yl)(Arylamino)Methylphosphonates. Pest Manag. Sci., 2019, 75: 3273-3281.

[30] Yan Zhang, Zhengming Li, Haibin Song, Baolei Wang*. Synthesis, Structure and Biological Activities of Novel 2-(Trifluoromethyl)-6- arylimidazo[2,1-b][1,3,4]-thiadiazole (bis-)Mannich Base Derivatives Containing Substitutedpiperazine Moiety. Chin. J. Chem., 2018, 36: 635-638.

[29] Qiao-Xia Liu, Bao-Lei Wang*, Ming-Zhen Mao, Li-Xia Xiong, Zheng-Ming Li. Synthesis and pesticidal activities of novel anthranilic diamides containing pyridylpyrazole and iminodithiocarbamate or thiosemicarbazone motifs. Phosphorus Sulfur Silicon Relat. Elem., 2018, 193(9): 593-599.

[28] Bao-Lei Wang*, Hong-Wei Zhu, Zheng-Ming Li, Li-Zhong Wang, Xiao Zhang, Li-Xia Xiong, Hai-Bin Song. Synthesis, Biological Evaluation and SAR Analysis of Novel Poly Heterocyclic Compounds Containing Pyridylpyrazole Group. Pest Manag. Sci., 2018, 74: 726-736.

[27] Bao-Lei Wang*, Li-Yuan Zhang, Xing-Hai Liu, Yi Ma, Yan Zhang, Zheng-Ming Li*, Xiao Zhang. Synthesis, biological activities and SAR studies of new 3-substitutedphenyl-4-substitutedbenzylideneamino-1,2,4-triazole Mannich bases and bis-Mannich bases as ketol-acid reductoisomerase inhibitors. Bioorg. Med. Chem. Lett., 2017, 27: 5457-5462.

[26] Bao-Lei Wang*, Yan Zhang, Xing-Hai Liu, Li-Yuan Zhang, Yi-Zhou Zhan, Xiao Zhang, Li-Zhong Wang, Yong-Hong Li, Zheng-Ming Li*. Synthesis and biological activity of novel dimethylpyrazole and piperazine-containing (bis)1,2,4-triazole derivatives. Phosphorus Sulfur Silicon Relat. Elem., 2017: 192, 34-41.

[25] Bao-Lei Wang, Yan-Xia Shi, Shu-Jun Zhang, Yi Ma, Hong-Xue Wang, Li-Yuan Zhang, Wei Wei, Xing-Hai Liu, Yong-Hong Li, Zheng-Ming Li*, Bao-Ju Li*. Syntheses, biological activities and SAR studies of novel carboxamide compounds containing piperazine and arylsulfonyl moieties. Eur. J. Med. Chem., 2016, 117: 167-178.

[24] Bao-Lei Wang*, Li-Yuan Zhang, Yi-Zhou Zhan, Yan Zhang, Xiao Zhang, Li-Zhong Wang, Zheng-Ming Li*. Synthesis and biological activities of novel 1,2,4-triazole thiones and bis(1,2,4-triazole thiones) containing phenylpyrazole and piperazine moieties. J. Fluorine Chem., 2016, 184: 36-44.

[23] Yan Zhang, Xing-Hai Liu, Yi-Zhou Zhan, Li-Yuan Zhang, Zheng-Ming Li, Yong-Hong Li, Xiao Zhang, Bao-Lei Wang*. Synthesis and biological activities of novel 5-substituted-1,3,4-oxadiazole Mannich bases and bis-Mannich bases as ketol-acid reductoisomerase inhibitors. Bioorg. Med. Chem. Lett., 2016, 26: 4661-4665.

[22] Bao-Lei Wang*, Yi-Zhou Zhan, Li-Yuan Zhang, Yan Zhang, Xiao Zhang, Zheng-Ming Li*. Synthesis and fungicidal activities of novel 1,2,4-triazole thione derivatives containing 1,2,3-triazole and substituted piperazine moieties. Phosphorus Sulfur Silicon Relat. Elem., 2016, 191: 48-54.

[21] Li-Yuan Zhang, Bao-Lei Wang*, Yi-Zhou Zhan, Yan Zhang, Xiao Zhang, Zheng-Ming Li*. Synthesis and biological activities of some fluorine- and piperazine-containing 1,2,4-triazole thione derivatives. Chin. Chem. Lett., 2016, 27: 163-167.

[20] Li-Yuan Zhang, Bao-Lei Wang*, Yi-Zhou Zhan, Xue-Wen Hua, Ming Liu, Xiao Zhang, Hai-Bin Song, Zheng-Ming Li*. Synthesis and biological activity of novel N-glucosides containing substituted piperazine moiety. Lett. Drug Des. Discov., 2016, 13 (4): 343-351.

[19] Yizhou Zhan, Baolei Wang*, Liyuan Zhang, Yan Zhang, Xiao Zhang, Zhengming Li*, Haibin Song. Studies on the Synthesis, Structure and Biological Activities of Novel Arylaminoformyl-containing 1-Cyano-1-cycloproane Carboxylic Acid Amides Based on Ugi Reaction. Acta Chim. Sinica, 2015, 73, 1173-1181.

[18] Baolei Wang, Yanxia Shi, Yizhou Zhan, Liyuan Zhang, Yan Zhang, Lizhong Wang, Xiao Zhang, Yonghong Li, Zhengming Li*, Baoju Li*. Synthesis and Biological Activity of Novel Furan/Thiophene and Piperazine-Containing (Bis)1,2,4-triazole Mannich Bases. Chin. J. Chem., 2015, 33(10): 1124-1134.

[17] Bao-Lei Wang*, Jing Wu, Qiao-Xia Liu, Yong-Hong Li, Hai-Bin Song, Zheng-Ming Li*. Synthesis, structure, and biological activities of [5-(arylthio/sulfinyl/sulfonyl)-3-methyl-1-phenyl-1H-pyrazol-4-yl]-arylmethanones. Phosphorus Sulfur Silicon Relat. Elem., 2015, 190(1): 66-78.

[16] Bao-Lei Wang*, Qing-Nan Li, Yi-Zhou Zhan, Li-Xia Xiong, Shu-Jing Yu, Zheng-Ming Li*. The synthesis and biological activities of [5-(4-substituted phenylsulfinyl/sulfonyl)-1,3-dimethyl-1H-pyrazol-4-yl]-arylmethanones. Phosphorus Sulfur Silicon Relat. Elem., 2014, 189: 483-491.

[15] Bao-Lei Wang, Hong-Wei Zhu, Yi Ma, Li-Xia Xiong, Yong-Qiang Li, Yu Zhao, Ji-Feng Zhang, You-Wei Chen, Sha Zhou, Zheng-Ming Li*. Synthesis, Insecticidal Activities, and SAR Studies of Novel Pyridylpyrazole Acid Derivatives Based on Amide Bridge Modification of Anthranilic Diamide Insecticides. J. Agric. Food Chem., 2013, 61: 5483-5493.

[14] Zhang, Ji-Feng ; Liu, Chen; Ma, Yi; Wang, Bao-Lei*; Xiong, Li-Xia; Yu, Shu-Jing; Li, Zheng-Ming*. Synthesis of Novel 3-Chloropyridin-2-yl-Pyrazole Derivatives and their Insecticidal, Fungicidal Activities and QSAR Study. Lett. Drug Des. Discov., 2013, 10(6): 497-506.

[13] Wang Baolei, Ma Yi, Xiong Lixia, Li Zhengming. Synthesis and Insecticidal Activity of Novel N-Pyridylpyrazole Carbonyl Thioureas. Chin. J. Chem., 2012, 30: 815-821.

[12] Ji-Feng Zhang, Jun-Ying Xu, Bao-Lei Wang, Yu-Xin Li, Li-Xia Xiong, Yong-Qiang Li, Yi Ma, Zheng-Ming Li. Synthesis and Insecticidal Activities of Novel Anthranilic Diamides Containing Acylthiourea and Acylurea. J. Agric. Food Chem., 2012, 60: 7565-7572.

[11] Wang Bao-Lei, Liu Xing-Hai, Zhang Xiu-Lan, Zhang Ji-Feng, Song Hai-Bin, Li Zheng-Ming*. Synthesis, Structure and Biological Activity of Novel 1,2,4-Triazole Mannich Bases Containing a Substituted Benzylpiperazine Moiety. Chem. Biol. Drug Des., 2011, 78: 42-49.

[10] Wang, Bao-Lei; Shi, Yan-Xia; Ma, Yi; Liu, Xing-Hai; Li, Yong-Hong; Song, Hai-Bin; Li, Bao-Ju*; Li, Zheng-Ming*. Synthesis and Biological Activity of Some Novel Trifluoromethyl-Substituted 1,2,4-Triazole and Bis(1,2,4-Triazole) Mannich Bases Containing Piperazine Rings. J. Agric. Food Chem., 2010, 58(9): 5515-5522.

[9] Wang, B. L.; Ma, R. D.; Li, Y. H.; Song, H. B.; Li, Z. M. Synthesis, Structure and Biological Activity of 2- 4-(5-Substituted-1,3,4-oxadiazol-2-yl)phenoxy Propanoate/Acetate. Chin. J. Org. Chem., 2010, 30(1): 92-97. 

[8] Wang, B. L.; Liu, X. H.; Li, Z. M., Synthesis and Characterization of O,O-Dimethyl-N-(2,2,2-trichloro- 1-arylaminoethyl) Phosphoramidothioates. Phosphorus Sulfur Silicon Relat. Elem., 2009, 184(9): 2281-2287. 

[7] Bao-Lei Wang, Yong-Hong Li, Jian-Guo Wang, Yi Ma, Zheng-Ming Li. Molecular design, synthesis and biological activities of amidines as new ketol-acid reductoisomerase inhibitors. Chin. Chem. Lett., 2008, 19: 651-654.

[6] WANG Bao-Lei, LI Zheng-Ming, LI Yong-Hong, WANG Su-Hua. Synthesis and Herbicidal Activities of 4-Alkoxy/benzyloxyphenyltetrazoles and 1,3,4-Oxadiazoles. Chem. J. Chin. U., 2008, 29(1): 90-94.

[5] Bao-Lei Wang, Zheng-Ming Li, Yong-Hong Li, Su-Hua Wang. Syntheses and biological activities of ethyl N-hydroxy-N-(substituted)phenyloxamates as KARI inhibitors. Chem. Res. Chin. U., 2007, 23(3): 280-283.

[4] Bao-Lei Wang, Ronald G Duggleby, Zheng-Ming Li, Jian-Guo Wang, Yong-Hong Li, Su-Hua Wang, Hai-Bin Song. Synthesis, crystal structure and hebricidal activity of mimics of intermediates of the KARI reaction. Pest Manag. Sci., 2005, 61: 407-412.

[3] WANG Bao-Lei, WANG Jian-Guo, MA Yi, LI Zheng-Ming, LI Yong-Hong, WANG Su-Hua. Molecular Docking and 3D-QSAR Research of Amidines of KARI Inhibitor. Acta Chimica Sinica, 2006, 64(13): 1373-1378.

[2] WANG Bao-Lei, LI Zheng-Ming, MA Yi, WANG Jian-Guo, LUO Xiao-Min, ZUO Zhi-Li. 3D-Database Searching Based on the Crystal Structure of Ketol-acid Reductoisomerase (KARI) Complex. Chin. J. Org. Chem., 2004, 24(8): 973-976.

[1] Wang Bao-Lei, Ma Ning, Wang Jian-Guo, Ma Yi, Li Zheng-Ming, Li Yong-Hong. 3D-QSAR Analysis of New Sulfonylureas Related to Their Herbicidal Activity. Acta Physico-chimica Sinica, 2004, 20(6): 577-581.

部分授权专利如下:

[5] 1,2,4-三唑环并[4,3-a]稠合哌嗪的曼尼希碱类衍生物及其制备方法和应用. 中国发明专利, 授权号: ZL201610993675.X, 申请日: 2016年11月11日, 授权日: 2019年03月19日.

[4] 含三氟甲基和哌嗪的三唑Mannich碱类化合物及其制备与应用. 中国发明专利, 授权号: ZL201510603487.7, 申请日: 2015年09月17日, 授权日: 2019年03月05日.

[3] 含(杂)芳基和哌嗪的1,2,4-三唑硫酮衍生物及制备方法和应用. 中国发明专利, 授权号: ZL201510603490.9, 申请日: 2015年09月17日, 授权日: 2018年05月01日.

[2] 含哌嗪的1,3,4-噁二唑Mannich碱类化合物及制备与应用. 中国发明专利, 授权号: ZL201610039702.X, 申请日: 2016年01月20日;授权日: 2017年09月12日.

[1] 吡唑甲酰基硫脲衍生物与制备方法和应用. 中国发明专利, 授权号: ZL201110147505.7, 申请日: 2011年06月02日; 授权日: 2013年11月06日.

人才培养

指导研究生(含协助李正名院士指导硕博士生)已毕业17人。

教师办公管理系统 维护系统 会议室预约系统 院级仪器管理平台 化学学院论文评审系统