李静
李静 
博士 副教授
李静,博士,副教授,元素有机化学研究所,毕业于山东农业大学,山东济南人。
工作内容:教学科研
人才称号:
通讯地址:天津市海河教育园区同砚路38号,南开大学综合实验楼C418
电 话:022-85358387
电子邮件:jinglink@nankai.edu.cn
课题组网站:
研究领域:1、药理学;2、毒理学;3、糖化学生物学;4、药用植物学
教育及科研经历:

1997-2001 山东农业大学农学本科

2001-2004 山东农业大学农学硕士研究生

2004-2007 山东农业大学农学博士研究生

2007-2020 南开大学药学院

2020-今  南开大学化学院

目前主持国家自然科学基金面上项目1项(PKM2激活剂调控p53降低癌症化疗诱发心脏毒性的机制及临床验证),曾主持国家自然科学基金青年基金1项(糖基化信号途径中OGA的双催化功能及其调节机制),天津市自然科学基金一般项目1项(胰岛素受体信号途径中糖基化蛋白的代谢标记及应用研究),参与国家新药创制重大专项、国家973等项目6项。 

荣誉和奖励

2011年获得南开大学本科生创新科研“百项工程”一等奖指导教师;

2020 年获得南开大学校级本科生优秀毕业论文指导教师

科研成果与代表作

[1]Ding Y, Xue Q, Liu S, Hu K, Wang D, Wang T, Li Y, Guo H, Hao X, Ge W, Zhang Y, Li A, Li J*, Chen Y*, Zhang Q*. Identification of Parthenolide Dimers as Activators of Pyruvate Ki-nase M2 in Xenograft of Glioblastoma Multiforme in vivo. Journal of Medicinal Chemistry 2020 63 (4): 1597-1611 

[2] Guo J., Xue Q., Ma J., Liu K., Ge W., Liu W., Wang J., Zhang M., Li Q., Cai D., Shan C., Zhang C., Liu X., Li J.*, Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis. Frontiers in Oncology, 2019, 9: 993.

[3] Guo J., Zhang G., Ma J., Zhao C., Xue Q., Wang J., Liu W., Wang H., Liu N., Song Q., Li J.*, A detection and identification of O-GlcNAc-modified proteins using 6-azido-6-deoxy-N-acetyl-galactosamine. Organic & Biomolecular Chemistry, 2019,17, 4326-4334.

[4] Li S., Wang J.*, Zang L., Zhu H., Guo J.,Zhang J., Wen L., Chen Y.,Li Y., Chen X., Wang P G.*, Li J.*,Production of Glycopeptide Derivatives for Exploring Substrate Specificity of Human OGA Toward Sugar Moiety. Frontiers in Chemistry, 2019, 6: 646.

[5] Wang H., Guo J., Wang N., Wang J., Xue Q., Wang J., Liu W., Liu K., Cao X ., Zhao W., Xi R., Niu Y., Wang P., Li J.*, Ac4GlcNAcF3, an OGT-tolerated but OGA-resistant regulator for O-GlcNAcylation.  Bioorganic & Medicinal Chemistry Letters, 2019.2.15, 29(6): 802~805.

[6] Li J., Li S., Guo J., Li Q., Long J., Ma C., Ding Y., Yan C., Li L., Wu Z., Zhu H., Li K., Wen L., Zhang Q., Xue Q., Zhao C., Liu N., Ivanov I., Luo M., Xi R., Long H., Wang PG., Chen Y.., Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia. Journal of Medicinal Chemistry 2018, 61, 4155−4164.

[7] Jiang K., Zhu H., Li L., Guo Y., Gashash E., Ma C., Sun X., Li J.*, Zhang L.*, Wang PG.*. Sialic acid linkage-specific permethylation for improved profiling of protein glycosylation by MALDI-TOF MS. Analytica Chimica Acta, 2017, 981:53-61.

[8] Jiang K., Zhu H., Xiao C., Liu D., Garrett E., Wen L., Ma C.*, Li J.*, Wang PG.*. Solid-phase reductive amination for glycomic analysis. Analytica Chimica Acta, 2017, 962:32-40.

[9] Wen L., Jiang K., Zheng Y., Zhang M., Kondengaden SM., Li S., Huang K., Li J., Song J., Wang PG. Two-step Chemoenzymatic Detecting N-Acetylneuraminic acid-α(2-3)- galactose Glycans. JACS, 2016, 138 (36): 11473–11476.

[10] Wu Z., Jiang K., Zhu H., Ma C., Yu Z., Li L., Guan W., Liu Y., Zhu H., Chen Y., Li J., Cheng J., Wang PG., Site-directed glycosylation of peptide/protein with homogeneous O-linked eukaryotic N-glycans. Bioconjugate chemistry 2016, 27 (9), 1972–1975.

[11] Li J., Wen L., Zhu H., Li S., Huang K., Li X., Ma C., Qu J., Parameswaran A., Song J., Zhao W., Wang PG. An OGA-resistant Probe Allow Specific Visualization and Accurate Identification of O-GlcNAc-modified Proteins in Cells. ACS Chem Biol, 2016, 11 (11): 3002–3006.

[12] Li S., Zhu H., Wang J., Wang X., Li X., Ma C., Wen L., Yu B., Wang Y., Li J*., Wang PG.* Comparative analysis of Cu (I)-catalyzed alkyne-azide cycloaddition (CuAAC) and strain-promoted alkyne-azide cycloaddition (SPAAC) in O-GlcNAc proteomics. Electrophoresis. 2016, 37(11): 1431-1436.

[13] Li Z., Li T., Dai S., Xie X., Ma X., Zhao W., Li J.* & Wang P. G*. New insights into the pharmacological chaperone activity of C2 — substituted glucoimidazoles for the treatment of gaucher disease. ChemBioChem, 2013, 14 (10): 1239- 1247. (Co-corresponding authors)

[14] Li T., Li Z., Li J., Wang J., Guo L., Wang P.G., & Zhao W. Elevation of cellular O-GlcNAcylation level by a potent and selective O-GlcNAcase inhibitor based on tetrahydro- imidazopyridine scaffold. Bioorganic & Medicinal Chemistry Letters. 2012, (22): 6854–6857.

[15] Li J., Li Z., Li T., Lin L., Zhang Y., Guo L., Xu Y., Zhao W. & Wang P. Identification of a specific inhibitor of nOGA — a caspase-3 cleaved O-GlcNAcase variant during apoptosis. Biochemistry (Moscow), 2012, 77(2): 194-200.

[16] Li T., Guo L., Zhang Y., Wang J., Zhang Z., Li J., Zhang W., Lin J., Zhao W. & Wang, P. G. Structure–activity relationships in a series of C2 — substituted gluco-configured tetrahydroimidazopyridines as β-glucosidase inhibitors. Bioorganic & medicinal chemistry, 2011, 19 (7): 2136-2144. 

[17] Li T., Guo L., Zhang Y., Wang J., Li Z., Lin L., Zhang Z., Li L., Lin J., Zhao W.*, Li J.*, Wang P. G.* Design and synthesis of O-GlcNAcase inhibitors via ‘click chemistry’and biological evaluations. Carbohydrate Research, 2011, 346 (9): 1083-1092. 

[18] Li T., Guo L., Li Z., Wang J., Li J.* & Zhao W.* O-GlcNAcase Inhibitors. Progress in Chemistry, 2011, 8: 75-82. 

[19] Li J., Huang C., Zhang L., Lin L., Li Z., Wang P.*, Isoforms of human O-GlcNAcase show distinct catalytic efficiencies. Biochemistry (Moscow), 2010, 75(7): 938-943.

人才培养

已毕业硕士研究生2名,协助指导硕士研究生6名,博士研究生3名。


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