熊虎
熊虎
博士 特聘研究员
熊虎,博士,特聘研究员,分析科学研究中心,毕业于中科院上海有机化学研究所,河南省驻马店市人。
工作内容:教学科研
特殊人才称号:南开大学百青
通讯地址:天津市南开区卫津路94号南开大学化学楼南楼103室
电 话:
电子邮件:xionghu@nankai.edu.cn
课题组网站:https://www.x-mol.com/groups/Xiong_Hu
研究领域:近红外一区/二区荧光成像,基于mRNA的生物发光成像,光热/光动力治疗
教育及科研经历:

2005年-2009年,郑州大学,化学学士

2009年-2014年,中科院上海有机化学研究所,有机化学博士,导师:唐勇院士与谢作伟院士

2014年-2018年,美国德州大学西南医学中心,博士后,合作导师:Daniel J. Siegwart

2018年12月-至今,南开大学,分析科学研究中心,特聘研究员

荣誉和奖励

科研成果与代表作

代表作:

(1) Wu, P., Zhu, Y., Chen, L., Tian, Y., Xiong, H.* A Fast-Responsive OFF-ON Near-Infrared-II Fluorescent Probe for in Vivo Detection of Hypochlorous Acid in Rheumatoid Arthritis. Analytical Chemistry, 2021, 93, accepted.

(2) Xu, W., Wu, P., Li, X., Liu, S., Feng, L., Xiong, H.* Two birds with one stone: A highly sensitive near-infrared BODIPY-based fluorescent probe for the simultaneous detection of Fe2+ and H+ in vivo. Talanta, 2021, 233, 122601.

(3) Wu, P., Siegwart, D. J., Xiong, H.* Recent Advances in the Development of Targeted Fluorescent Probes for the Detection of Metastatic Bone Cancer. SCIENCE CHINA Chemistry, 2021, 64, 1283–1296.

(4) Liu, S., Zhu, Y., Wu, P., Xiong, H.* Highly Sensitive D−A−D-Type Near-Infrared Fluorescent Probe for Nitric Oxide Real-Time Imaging in Inflammatory Bowel Disease. Analytical Chemistry, 2021, 93, 4975−4983.

(5) Xiong, H.*, Liu, S., Wei, T., Cheng, Q., Siegwart, D. J. Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo. Journal of Controlled Release, 2020, 325, 198–205.

(6) Xiong, H., Zhou, K., Yan, Y., Miller, J. B., Siegwart, D. J.* Tumor activated water-soluble photosensitizers for near-infrared photodynamic cancer therapy. ACS Applied Materials & Interfaces, 2018, 10, 16335−16343.

(7) Xiong, H., Zuo, H., Yan, Y., Occhialini, G., Zhou, K., Wan, Y., Siegwart, D. J.* High-contrast fluorescence detection of metastatic breast cancer including bone and liver micrometastases via size-controlled pH-activatable water-soluble probes. Advanced Materials, 2017, 29, 1700131.

(8) Miller, J. B., Zhang, S., Kos, P., Xiong, H., Zhou, K., Perelman, S. S., Zhu, H., Siegwart, D. J.* Non-viral CRISPR/Cas gene editing in vitro and in vivo enabled by synthetic nanoparticle co-delivery of Cas9 mRNA and sgRNA. Angew. Chem. Int. Ed. 2017, 56, 1059−1063.

(9) Xiong, H., Kos, P., Yan, Y., Zhou, K., Miller, J. B., Elkassih, S., Siegwart, D. J.* Activatable water-soluble probes enhance tumor imaging by responding to dysregulated pH and exhibiting high tumor-to-liver fluorescence emission contrast. Bioconjugate Chemistry, 2016, 27, 1737−1744.

(10) Xiong, H., Xu, H., Liao, S., Xie, Z.*, Tang, Y.* Copper-Catalyzed Highly Enantioselective Cyclopentannulation of Indoles with Donor-Acceptor Cyclopropanes. J. Am. Chem. Soc. 2013, 135, 7851−7854. (Highlighted in SYNFORM 2013, 10, 122.)

人才培养

目前实验室在培硕士生5名,博士生6名。

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