熊虎

师资力量

特聘

熊虎

博士特聘研究员

熊虎，博士，特聘研究员，分析科学研究中心，毕业于中科院上海有机化学研究所，河南省驻马店市人。
工作内容：教学科研
人才称号：国家“四青”人才
通讯地址：天津市南开区卫津路94号南开大学化学楼南楼103室
电话：
电子邮件：xionghu@nankai.edu.cn
课题组网站：https://www.x-mol.com/groups/Xiong_Hu
研究领域：近红外荧光成像，细胞特异性生物发光成像，mRNA精准递送

教育及科研经历：

2005年-2009年，郑州大学，化学学士

2009年-2014年，中科院上海有机化学研究所，有机化学博士，导师：唐勇院士与谢作伟院士

2014年-2018年，美国德州大学西南医学中心，博士后，合作导师：Daniel J. Siegwart

2018年12月-至今，南开大学，分析科学研究中心，特聘研究员

荣誉和奖励

科研成果与代表作

1) Chen, Z., Yang, Y., Qiu, X., Zhou, H., Wang, R., Xiong, H.* Crown-Like Biodegradable Lipids Enable Lung-Selective mRNA Delivery and Dual-Modal Tumor Imaging In Vivo. J. Am. Chem. Soc. 2024, 146, 34209–34220.

2) Chen, Z., Tian, Y., Yang, J., Wu, F., Liu, S., Cao, W., Xu, W., Hu, T., Siegwart, D. J., Xiong, H.* Modular Design of Biodegradable Ionizable Lipids for Improved mRNA Delivery and Precise Cancer Metastasis Delineation In Vivo. J. Am. Chem. Soc. 2023, 145, 24302–24314.

3) Zhu, Y., Wu, P., Liu, S., Yang, J., Wu, F., Cao, W., Yang, Y., Zheng, B., Xiong, H.* Electron-Withdrawing Substituents Allow Boosted NIR-II Fluorescence in J-Type Aggregates for Bioimaging and Information Encryption. Angew. Chem. Int. Ed. 2023, 62, e202313166.

4) Tian, Y., Chen, Z., Liu, S., Wu, F., Cao, W., Pang, D.-W.*, Xiong, H.* “Dual-Key-and-Lock” NIR-II NSCyanines Enable High-Contrast Activatable Phototheranostics in Extrahepatic Diseases. Angew. Chem. Int. Ed. 2023, 62, e202309768.

5) Zhu, Y., Wu, F., Zheng, B., Yang, Y., Yang, J., Xiong, H.* Electron-Withdrawing Substituents Enhance Type-I PDT and NIR-II Fluorescence of BODIPY J-aggregates for Bioimaging and Cancer Therapy. Nano Lett. 2024, 24, 8287–8295.

6) Liu, S., Xu, W., Li, X., Pang, D.-W., Xiong, H.* BOIMPY-based NIR-II Fluorophore with High Brightness and Long Absorption beyond 1000 nm for In Vivo Bioimaging: Synergistic Steric Regulation Strategy. ACS Nano 2022, 16, 17424–17434.

7) Wu, P., Zhu, Y., Liu, S., Xiong, H.* Modular Design of High-Brightness pH-Activatable Near-Infrared BODIPY Probes for Noninvasive Fluorescence Detection of Deep-Seated Early Breast Cancer Bone Metastasis: Remarkable Axial Substituent Effect on Performance. ACS Cent. Sci. 2021, 7, 2039–2048.

8) Yang, K., Tian, Y., Zheng, B., Wu, F., Hu, T., Yang, Y., Pan, J., Xiong, H.*, Wang, S.* Fast-Responsive HClO-Activated Near-Infrared Fluorescent Probe for In Vivo Diagnosis of Inflammatory Bowel Disease and Ex Vivo Optical Fecal Analysis. Anal. Chem. 2024, 96, 12065–12073.

9) Chen, Z., Yang, Y., Tian, Y., Yang, J., Xiong, H.* Diagnosis of Non-alcoholic Fatty Liver Disease via a H₂S-responsive Bioluminescent Probe Combined with Firefly Luciferase mRNA Delivery. Anal. Chem. 2024, 96, 9236–9243.

人才培养

目前实验室在培硕士生5名，博士生6名。