分子印迹与分子识别；纳米荧光探针与生物成像

1981年9月-1985年7月，河北大学，学士学位

1985年9月-1988年7月，山西大学，硕士学位

1994年9月-1997年7月，厦门大学，博士学位

1997年9月-1999年5月，东南大学，博士后

1999年5月-现在，南开大学化学学院，副教授，教授

获2013年南开大学第五届“敬业”奖教金教学二等奖

获2005年天津市自然科学奖二等奖（第三完成人）

长期从事分子印迹聚合物的制备及其在靶向药物递送、生物成像、分离、传感、模拟酶催化等方面的应用研究。

代表性论文：

1. Yao-Jia Ma, Si Li, Ya-Ting Qin, Xi-Wen He, Wen-You Li*, Yu-Kui Zhang, Multimode sensing platform based on turn-on fluorescent silicon nanoparticles for monitoring of intracellular pH and GSH, Analytical Chemistry, 2023, 95(16): 6664-6671.

2. Ya-Ting Qin, Hui Peng, Xi-Wen He, Wen-You Li*, Yu-Kui Zhang, Highly effective drug delivery and cell imaging using fluorescent double-imprinted nanoparticles by targeting recognition of the epitope of membrane protein, Analytical Chemistry, 2019, 91(20): 12696-12703.

3. Ya-Kun Dou, Yang Chen, Xi-Wen He, Wen-You Li*, Yu-Hao Li*, Yu-Kui Zhang, Synthesis of water-dispersible Mn²⁺ functionalized silicon nanoparticles under room temperature and atmospheric pressure for fluorescence and magnetic resonance dual-modality imaging, Analytical Chemistry, 2017, 89(21): 11286-11292.

4. Hong-Li Ye, Shi-Jiao Cai, Si Li, Xi-Wen He, Wen-You Li*, Yu-Hao Li* and Yu-Kui Zhang, One-pot microwave synthesis of water-dispersible, high fluorescence silicon nanoparticles and their imaging applications in vitro and in vivo, Analytical Chemistry, 2016, 88 (23): 11631-11638.

5. Xing-Hui Ren, Lei Shi, Zi-Bo Ma, Da-Wei Wang, Xi-Wen He, Wen-You Li*, Yu-Kui Zhang*, Inhibition of nucleotide metabolism with dual-template epitope imprinted nanoparticles for targeted HER2+ tumor therapy, Chemical Engineering Journal, 2024, 481: 148739.

6. Da-Wei Wang, Xing-Hui Ren, Yao-Jia Ma, Fang-Qi Wang, Xi-Wen He, Wen-You Li*,  Yu-Kui Zhang*, Dual-template epitope imprinted nanoparticles for anti-glycolytic tumor-targeted treatment, Journal of Colloid and Interface Science, 2025, 683: 890-905.

7. Yao-Jia Ma, Lei Shi, Ya-Ting Qin, Xi-Wen He, Wen-You Li*, Yu-Kui Zhang, Dual template molecularly imprinted polymers targeting blockade of CD47 for enhanced macrophage phagocytosis and synergistic antimetabolic therapy, ACS Applied Materials & Interfaces, 2024, 16(32): 41788-41799.

8. Yao-Jia Ma, Zheng-Chen Su, Fang-Qi Wang, Xi-Wen He, Wen-You Li*, Yu-Kui Zhang, CuNCs-based pH-responsive degradable nanoplatform for enhanced CDT/IIT synergistic tumor therapy in a “one-stone-two-birds” manner, ACS Materials Letters, 2024, 6(7): 2515-2525.

9. Yan Zhang, Yu-Sheng Feng, Xing-Hui Ren, Xi-Wen He, Wen-You Li*, Yu-Kui Zhang, Bimetallic molecularly imprinted nanozyme: Dual-mode detection platform, Biosensors & Bioelectronics, 2022, 196: 113718.

10. Yan Zhang, Hai-Yan Wang, Xi-Wen He, Wen-You Li*, Yu-Kui Zhang, Homochiral fluorescence responsive molecularly imprinted polymer: Highly chiral enantiomer resolution and quantitative detection of L-penicillamine, Journal of Hazardous Materials, 2021, 412: 125249.

人才培养