博士 特聘研究员
董建桐，博士，特聘研究员，分析科学研究中心，毕业于北京大学，河南南阳人。
工作内容：教学科研
人才称号：国家“四青”人才
通讯地址：天津市津南区海河教育园同砚路38号南开大学津南校区前沿交叉大楼B座503
电 话：
电子邮件：jtdong2025@nankai.edu.cn
课题组网站：https://www.x-mol.com/groups/dong_jiantong
研究领域：
1.基于微流控芯片的病原体、外泌体及类器官分析
2.基于核酸动态组装的仿生、传感与生物成像系统
3.基于纳米材料靶向递送生物探针的精准医学分析
教育及科研经历：
2010－2014，山东大学，化学基地专业，理学学士
2014－2021，北京大学，分析化学专业，理学博士
2017－2019，美国加州大学洛杉矶分校，联合培养
2021－2025，以色列耶路撒冷希伯来大学，博士后
2025年至今，南开大学化学学院，研究生/博士生导师
国家级海外优秀青年人才（2025）
中国化学会第一届仿生材料化学学术会议优秀青年学者奖（2025）
北京市普通高等学校优秀毕业生（2021）
近年来，已在仿生微流控芯片分析、核酸动态传感与成像以及生物医学检测领域以第一/通讯作者（含共同）接收/发表SCI 论文20余篇，包括Nat. Chem.（1篇），J. Am. Chem. Soc.（4篇），Sci. Adv.（2篇），Angew. Chem. Int. Ed.（2篇），Nat. Commun.（1篇），Adv. Mater.（1篇），Chem. Soc. Rev.（1篇），ACS Nano（2篇），Adv. Funct. Mater.（1篇），Anal. Chem.（1篇）等期刊。
1. J. Dong, I. Willner*, Synthetic Dynamic Transcription Frameworks and Their Applications, Nat. Chem., 2025, in press.
2. J. Dong, F. Xia*, F. Huang*, and I. Willner*, Dynamic Transcription Machineries in Protocells, J. Am. Chem. Soc., 2025, 147, 22, 18359–18373.
3. J. Dong, I. Willner*, Photochemically Triggered, Transient, and Oscillatory Transcription Machineries Guide Temporal Modulation of Fibrinogenesis, J. Am. Chem. Soc., 2025, 147, 2216–2227.
4. J. Dong, I. Willner*, Transient Transcription Machineries Modulate Dynamic Functions of G-Quadruplexes: Temporal Regulation of Biocatalytic Circuits, Gene Replication and Transcription, Angew. Chem. Int. Ed., 2023, 62, e202307898.
5. J. Dong, M. P. O’ Hagan, and I. Willner*, Switchable and Dynamic G-Quadruplexes and Their Applications, Chem. Soc. Rev., 2022, 51, 7631–7661.
6. J. Dong, I. Willner*, Dynamic Transcription Machineries Guide the Synthesis of Temporally Operating DNAzymes, Gated and Cascaded DNAzyme Catalysis, ACS Nano, 2023, 17, 687–696.
7. J. Dong, Y. Ouyang, J. Wang, M. P. O’ Hagan, and I. Willner*, Assembly of Dynamic Gated and Cascaded Transient DNAzyme Networks, ACS Nano, 2022, 16, 6153.
8. J. Dong, Y. J. Jan, J. Cheng, R. Y. Zhang, M. Meng, M. Smalley, P.-J. Chen, X. Tang, P. Tseng, L. Bao, T.-Y. Huang, D. Zhou, Y. Liu, X. Chai, H. Zhang, A. Zhou, V. G. Agopian, E. M. Posadas, J.-J. Shyue, S. J. Jonas, P. S. Weiss, M. Li*, G. Zheng*, H.-h. Yu*, M. Zhao*, H.-R. Tseng*, and Y. Zhu*, Covalent Chemistry on Nanostructured Substrates Enables Noninvasive Quantification of Gene Rearrangements in Circulating Tumor Cells, Sci. Adv., 2019, 5, eaav9186.
9. J. Dong#, J.-F. Chen#, M. Smalley, M. Zhao, Z. Ke*, Y. Zhu*, and H.-R. Tseng*, Nanostructured Substrates for Detection and Characterization of Circulating Rare Cells: From Materials Research to Clinical Applications, Adv. Mater., 2020, 32, 1903663.
10. J. Dong, R. Y. Zhang, N. Sun, J. Hu, M. D. Smalley, A. Zhou, Y. Hua, W. Rothermich, M. Chen, J. Chen, J. Ye, P.-C. Teng, D. Qi, J. A. Toretsky, J. S. Tomlinson, M. Li, P. S. Weiss, S. J. Jonas, N. Federman, L. Wu, M. Zhao, H.-R. Tseng and Y. Zhu, Sarcoma-Derived Extracellular Vesicles: Coupling Nanostructured Microchips with Covalent Chemistry Enables Purification of Sarcoma-Derived Extracellular Vesicles for Downstream Functional Studies, Adv. Funct. Mater., 2020, 30, 2070322.
11. M. Ji, J. Dong*, Z. Ye, J. Kang, G. Han, X. Hong, Y, Wei, X, Chen*, W. Sun*, and D. Liu*, Endogenous HClO-Gated Cascade MicroRNA Imaging for Precise Diagnosis of Atherosclerosis In Vivo, J. Am. Chem. Soc., 2025, 147, 7113–7126. (*co-corresponding author)
12. X. Wang, J. Dong*, J. Kang, X. Chen, X. Hong, J. Chen, W. Du, H. Cai, and D. Liu*, Self-Adaptive Release of Stem Cell-Derived Exosomes from a Multifunctional Hydrogel for Accelerating MRSA-Infected Diabetic Wound Repair, J. Am. Chem. Soc., 2025, 147, 16362–16378. (*co-corresponding author)
13. H. Liu#, J. Dong#, R. Wu#, J. Dai, X. Lou, F. Xia, I. Willner and F. Huang, Light-Triggered CRISPR/Cas12a for Genomic Editing and Tumor Regression, Angew. Chem. Int. Ed., 2025, e202502892. (#co-first author)
14. H. Liu#, J. Dong#, Z. Duan, F. Xia, I. Willner and F. Huang, Light-activated CRISPR-Cas12a for amplified imaging of microRNA in cell cycle phases at single-cell levels, Sci. Adv., 2024, 10, eadp6166. (#co-first author)
15. Y. Afshar#, J. Dong#, P. Zhao, L. Li, S. Wang, R. Y. Zhang, C. Zhang, O. Yin, C. S. Han, B. D. Einerson, T. L. Gonzalez, H. Zhang, A. Zhou, Z. Yang, S.-J. Chou, N. Sun, J. Cheng, H. Zhu, J. Wang, T. X. Zhang, Y.-T. Lee, J. J. Wang, P.-C. Teng, P. Yang, D. Qi, M. Zhao, M.-S. Sim, R. Zhe, J. D. Goldstein, J. Williams, X. Wang, Q. Zhang, L. D. Platt, C. Zou, M. D. Pisarska, H.-R. Tseng and Y. Zhu, Circulating trophoblast cell clusters for early detection of placenta accreta spectrum disorders, Nat. Commun., 2021, 12, 4408. (#co-first author)
人才培养
每年招收硕士生2-3名，博士生2名，招收推免生、直博生，并长期招聘博士后。与美国、加拿大、英国、以色列等诸多名校合作密切，推荐出国留学机会。热烈欢迎具有化学、材料、生物、医学等背景的优秀人才随时联系加入我们团队。
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